Vice Chair of Research
Department of Genetics and Genome Sciences
School of Medicine
Professor
Department of Genetics and Genome Sciences
School of Medicine
Member
Cancer Genomics and Epigenomics Program
Case Comprehensive Cancer Center
I research tissue-specific and temporal regulation of gene expression in health and disease. In addition, I study functional genomics of regulatory elements, transcriptional networks, and Chromatin architecture.
Research Information
Research Interests
Dr. Harris's research career has been devoted to human molecular genetics, with a particular interest in the molecular genetics of epithelial diseases including cystic fibrosis (CF) and aspects of epithelial cell biology relevant to cancer. Over many years her team focused on elucidating the mechanisms that confer tissue-specific and temporal regulation on the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, errors in which cause CF.
Research Projects
- CFTR gene regulation in poorly studied tissues. We now have a clear 3D understanding of how CFTR is regulated in the major cell types in the epithelium lining the lung and the intestines. However, CFTR also has important roles in other tissues including the pancreas, gall bladder, reproductive system and sweat glands. Current research will determine the CFTR gene regulatory mechanisms at these sites.
- Early development of CF disease. We are investigating CF disease progression before birth using the CF sheep models. Advanced protocols of functional genomics, including single cell RNA-seq, multiomics and spatial transcriptomics, are being used. These approaches are complemented by mechanistic studies in organoids to investigate lung and pancreatic disease at single cell resolution. Outcomes will enhance understanding of early disease in pwCF and may open new opportunities for treatment.
- Transcriptional networks coordinating luminal environment in the human epididymis. The epithelial cells lining the male genital ducts have a key role in sperm maturation, with regional distribution of functions that are species-specific. Combining functional genomics, bioinformatics and organoid assays we are elucidating hormonal control mechanisms that coordinate human epididymis function.